Protein Kinase Ontology (ProKinO) – An integrated knowledge graph conceptualizing the wealth of information connecting protein kinase sequence, structure, function, evolution and disease (cancer) in human and machine readable format.
Presenters: Saber Soleymani, Krystof Kochut, Natarajan Kannan, UGA (IDG CEIT)
Demo Outcome: Demonstrations will focus on ProKinO knowledge graph mining using SPARQL and visualization tools for mining kinase sequence and regulatory features in light of structural models (AlphaFold) and crystal structures. Attendees will learn to formulate new testable hypotheses on understudied dark kinases using evolutionary and functional context of the entire kinome in one place.
Link to Digital tool:
https://prokino.uga.edu/
IDG Grant: CEIT-UGA U01CA239106
For more information on IDG Digital Tool Fest 2021, visit
https://druggablegenome.net/IDG-Digital-Tool-Fest-Fall2021
Visit
https://druggablegenome.net/ for more information on IDG Consortium
Тэги:
#IDG #KMC #DRGC #Druggable_Genome #NIH #RDOC #Kinase #GPCR #Ion_Channel #CEIT #Informatics